Correlation between Protein Function and Ligand Binding Profiles
نویسندگان
چکیده
منابع مشابه
Correlation between protein function and ligand binding profiles.
We report that proteins with the same function bind the same set of small molecules from a standardized chemical library. This observation led to a quantifiable and rapidly adaptable method for protein functional analysis using experimentally derived ligand binding profiles. Ligand binding is measured using a high-throughput NMR ligand affinity screen with a structurally diverse chemical librar...
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ژورنال
عنوان ژورنال: Journal of Proteome Research
سال: 2011
ISSN: 1535-3893,1535-3907
DOI: 10.1021/pr200015d